Wobbliness (ataxia) after Imidacloprid + Moxidectin (Advantage Multi) in cats

The FDA has received 530 reports of wobbliness (ataxia) in cats after Imidacloprid + Moxidectin. That is 6.5% of all reports for this medicine, compared with 4.7% across reports for all cat medicines.

530Reports
64%Marked serious
35%Recovered
9.1%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
138 38%
1–2 days
172 47%
3–7 days
20 5.5%
1–4 weeks
16 4.4%
Over a month
18 4.9%

How the animals did

Recovered
186 35%
Recovered with lasting effects
1 0.2%
Still unwell when reported
20 3.8%
Died
35 6.6%
Euthanised
13 2.5%
Not known
275 52%

Problems reported at the same time

Age of the animals

Under 1 year
102
1–3 years
123
4–7 years
131
8–11 years
83
12+ years
63

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause wobbliness (ataxia) in cats?
530 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Wobbliness (ataxia) with similar medicines

All reported side effects of Imidacloprid + Moxidectin in cats · Medicines most reported with wobbliness (ataxia)