Vocalising after Imidacloprid + Moxidectin (Advantage Multi) in cats

The FDA has received 213 reports of vocalising in cats after Imidacloprid + Moxidectin. That is 2.6% of all reports for this medicine, compared with 3.1% across reports for all cat medicines.

213Reports

63%Marked serious

39%Recovered

11%Died or euthanised

Same dayTypical onset

How soon it started

Same day

92 61%

1–2 days

30 20%

3–7 days

11 7.2%

1–4 weeks

13 8.6%

Over a month

6 3.9%

How the animals did

Recovered

84 39%

Still unwell when reported

9 4.2%

Died

14 6.6%

Euthanised

9 4.2%

Not known

97 46%

Problems reported at the same time

Behaviour change

77 36%

Restlessness or agitation

57 27%

52 24%

49 23%

46 22%

36 17%

34 16%

Application site reaction

29 14%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause vocalising in cats?: 213 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Vocalising with similar medicines

Vocalising after Spinosad (Comfortis) 150 reports · 1.3% of its reports
Vocalising after Nitenpyram (Capstar) 1,314 reports · 15% of its reports
Vocalising after Lufenuron 24 reports · 2.2% of its reports
Vocalising after Flumethrin + Imidacloprid (Seresto) 21 reports · 3.1% of its reports
Vocalising after Imidacloprid + Pyriproxyfen 30 reports · 4.6% of its reports
Vocalising after Fipronil 29 reports · 5.8% of its reports
Vocalising after Imidacloprid 21 reports · 8.3% of its reports

All reported side effects of Imidacloprid + Moxidectin in cats · Medicines most reported with vocalising