Lateral recumbency after Imidacloprid + Moxidectin (Advantage Multi) in cats

28 reports to the FDA describe lateral recumbency in cats given Imidacloprid + Moxidectin. That is 0.3% of all reports for this medicine, compared with 0.5% across reports for all cat medicines, so it is reported less often than average with this medicine.

28Reports
89%Marked serious
25%Recovered
50%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
7 29%
1–2 days
14 58%
3–7 days
1 4.2%
1–4 weeks
1 4.2%
Over a month
1 4.2%

How the animals did

Recovered
7 25%
Still unwell when reported
1 3.6%
Died
5 18%
Euthanised
9 32%
Not known
6 21%

Problems reported at the same time

14 50%
14 50%
Bradypnoea
6 21%
Decreased body temperature
6 21%

Age of the animals

Under 1 year
6
1–3 years
9
4–7 years
8
8–11 years
0
12+ years
5

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause lateral recumbency in cats?
28 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Lateral recumbency with similar medicines

All reported side effects of Imidacloprid + Moxidectin in cats · Medicines most reported with lateral recumbency