Excessive licking and/or grooming after Imidacloprid + Moxidectin (Advantage Multi) in cats

173 reports to the FDA describe excessive licking and/or grooming in cats given Imidacloprid + Moxidectin. That is 2.1% of all reports for this medicine, compared with 0.6% across reports for all cat medicines, so it is reported unusually often with this medicine.

173Reports
61%Marked serious
38%Recovered
2.3%Died or euthanised
1 daysTypical onset
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How soon it started

Same day
61 50%
1–2 days
25 20%
3–7 days
17 14%
1–4 weeks
18 15%
Over a month
2 1.6%

How the animals did

Recovered
65 38%
Still unwell when reported
2 1.2%
Died
4 2.3%
Not known
102 59%

Problems reported at the same time

Age of the animals

Under 1 year
16
1–3 years
39
4–7 years
44
8–11 years
39
12+ years
25

About this medicine

Imidacloprid kills fleas (spot-on or collar). Moxidectin prevents heartworm disease (monthly topical, or a 6- or 12-month injection for dogs).

Products with this combination include Advantage Multi. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Imidacloprid + Moxidectin cause excessive licking and/or grooming in cats?
173 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 1 day of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Excessive licking and/or grooming with similar medicines

All reported side effects of Imidacloprid + Moxidectin in cats · Medicines most reported with excessive licking and/or grooming