Elevated symmetrical dimethylarginine (sdma) after Frunevetmab (Solensia) in cats

The FDA has received 151 reports of elevated symmetrical dimethylarginine (sdma) in cats after Frunevetmab. That is 1.9% of all reports for this medicine, compared with 0.5% across reports for all cat medicines, so it is reported unusually often with this medicine.

151Reports

81%Marked serious

4.0%Recovered

21%Died or euthanised

19 daysTypical onset

How soon it started

Same day

23 17%

1–2 days

24 18%

3–7 days

9 6.7%

1–4 weeks

23 17%

Over a month

56 41%

How the animals did

Recovered

6 4.0%

Still unwell when reported

105 70%

Died

4 2.6%

Euthanised

27 18%

Not known

9 6.0%

Problems reported at the same time

114 75%

63 42%

38 25%

36 24%

35 23%

31 21%

29 19%

28 19%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

132

About this medicine

Frunevetmab reduces osteoarthritis pain in cats (monthly injection).

Products with this ingredient include Solensia. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Frunevetmab cause elevated symmetrical dimethylarginine (sdma) in cats?: 151 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 19 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Frunevetmab in cats · Medicines most reported with elevated symmetrical dimethylarginine (sdma)