Drooling after Dexmedetomidine (Dexdomitor) in cats

The FDA has received 235 reports of drooling in cats after Dexmedetomidine. That is 8.9% of all reports for this medicine, compared with 5.6% across reports for all cat medicines, so it is reported unusually often with this medicine.

235Reports

32%Marked serious

28%Recovered

10%Died or euthanised

Same dayTypical onset

How soon it started

Same day

149 82%

1–2 days

21 12%

3–7 days

4 2.2%

1–4 weeks

6 3.3%

Over a month

2 1.1%

How the animals did

Recovered

65 28%

Still unwell when reported

83 35%

Died

16 6.8%

Euthanised

8 3.4%

Not known

63 27%

Problems reported at the same time

70 30%

43 18%

34 14%

30 13%

26 11%

Restlessness or agitation

24 10%

Death

24 10%

Dilated pupils

22 9.4%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Dexmedetomidine sedation and pain relief (also an oral gel for noise anxiety).

Products with this ingredient include Dexdomitor, Sileo. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Dexmedetomidine cause drooling in cats?: 235 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Drooling with similar medicines

Drooling after Buprenorphine 306 reports · 5.5% of its reports

All reported side effects of Dexmedetomidine in cats · Medicines most reported with drooling