Gingival hyperplasia after Cyclosporine (Atopica) in cats

The FDA has received 42 reports of gingival hyperplasia in cats after Cyclosporine. That is 1.4% of all reports for this medicine, compared with 0.0% across reports for all cat medicines, so it is reported unusually often with this medicine.

42Reports

40%Marked serious

4.8%Recovered

7.1%Died or euthanised

52 daysTypical onset

How soon it started

Same day

3 13%

1–2 days

1 4.3%

3–7 days

2 8.7%

1–4 weeks

4 17%

Over a month

13 57%

How the animals did

Recovered

2 4.8%

Still unwell when reported

18 43%

Died

2 4.8%

Euthanised

1 2.4%

Not known

19 45%

Problems reported at the same time

Weight loss

8 19%

Gingivitis

5 12%

3 7.1%

3 7.1%

3 7.1%

2 4.8%

2 4.8%

Didn't work as expected

2 4.8%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Cyclosporine controls allergic skin disease and some immune conditions.

Products with this ingredient include Atopica. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Cyclosporine cause gingival hyperplasia in cats?: 42 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 52 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Cyclosporine in cats · Medicines most reported with gingival hyperplasia