Decreased heart rate after Buprenorphine in cats

The FDA has received 26 reports of decreased heart rate in cats after Buprenorphine. That is 0.5% of all reports for this medicine, compared with 0.1% across reports for all cat medicines, so it is reported unusually often with this medicine.

26Reports

58%Marked serious

50%Recovered

19%Died or euthanised

Same dayTypical onset

How soon it started

Same day

21 88%

1–2 days

2 8.3%

3–7 days

0 0.0%

1–4 weeks

0 0.0%

Over a month

1 4.2%

How the animals did

Recovered

12 46%

Recovered with lasting effects

1 3.8%

Still unwell when reported

6 23%

Died

4 15%

Euthanised

1 3.8%

Not known

2 7.7%

Problems reported at the same time

Low blood pressure

9 35%

Loss of appetite

5 19%

Pale mucous membrane

5 19%

Decreased body temperature

5 19%

Death

5 19%

Behaviour change

5 19%

Eye or vision problems

4 15%

Liver problems

4 15%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Buprenorphine pain relief (an opioid).

Questions owners ask

Can Buprenorphine cause decreased heart rate in cats?: 26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within the same day of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Buprenorphine in cats · Medicines most reported with decreased heart rate