Diabetic ketoacidosis after Bexagliflozin (Bexacat) in cats

The FDA has received 275 reports of diabetic ketoacidosis in cats after Bexagliflozin. That is 6.8% of all reports for this medicine, compared with 0.3% across reports for all cat medicines, so it is reported unusually often with this medicine.

275Reports

98%Marked serious

10%Recovered

37%Died or euthanised

5 daysTypical onset

How soon it started

Same day

21 8.8%

1–2 days

51 21%

3–7 days

68 29%

1–4 weeks

32 13%

Over a month

66 28%

How the animals did

Recovered

28 10%

Still unwell when reported

86 31%

Died

20 7.3%

Euthanised

81 29%

Not known

60 22%

Problems reported at the same time

149 54%

114 41%

113 41%

103 37%

77 28%

77 28%

77 28%

73 27%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

102

12+ years

About this medicine

Bexagliflozin treats diabetes in cats (oral, an SGLT2 inhibitor).

Products with this ingredient include Bexacat. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Questions owners ask

Can Bexagliflozin cause diabetic ketoacidosis in cats?: 275 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 5 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Diabetic ketoacidosis with similar medicines

Diabetic ketoacidosis after Velagliflozin (Senvelgo) 191 reports · 4.0% of its reports
Diabetic ketoacidosis after Insulin 66 reports · 1.8% of its reports

All reported side effects of Bexagliflozin in cats · Medicines most reported with diabetic ketoacidosis