Knuckling after Tramadol in dogs

26 reports to the FDA describe knuckling in dogs given Tramadol. That is 0.7% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

26Reports

81%Marked serious

12%Recovered

42%Died or euthanised

30 daysTypical onset

How soon it started

Same day

3 16%

1–2 days

0 0.0%

3–7 days

2 11%

1–4 weeks

5 26%

Over a month

9 47%

How the animals did

Recovered

3 12%

Still unwell when reported

9 35%

Died

4 15%

Euthanised

7 27%

Not known

3 12%

Problems reported at the same time

11 42%

9 35%

9 35%

7 27%

7 27%

Proprioception deficit

6 23%

Weakness

6 23%

Abnormal radiograph finding

6 23%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Tramadol cause knuckling in dogs?: 26 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 30 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Knuckling with similar medicines

Knuckling after Melarsomine (Immiticide) 33 reports · 0.1% of its reports
Knuckling after Polysulfated Glycosaminoglycan 35 reports · 0.6% of its reports
Knuckling after Chondroitin + Glucosamine 20 reports · 0.8% of its reports

All reported side effects of Tramadol in dogs · Medicines most reported with knuckling