Hyperexcitation after Tiletamine + Zolazepam in dogs

77 reports to the FDA describe hyperexcitation in dogs given Tiletamine + Zolazepam. That is 5.3% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

77Reports

0.0%Marked serious

2.6%Recovered

7.8%Died or euthanised

–Typical onset

How the animals did

Recovered

2 2.6%

Still unwell when reported

1 1.3%

Died

6 7.8%

Not known

68 88%

Problems reported at the same time

25 32%

18 23%

10 13%

7 9.1%

6 7.8%

Spasm

5 6.5%

Death

5 6.5%

Seizures

5 6.5%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Tiletamine + Zolazepam cause hyperexcitation in dogs?: 77 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyperexcitation with similar medicines

Hyperexcitation after Butorphanol 22 reports · 0.5% of its reports
Hyperexcitation after Propofol 54 reports · 1.8% of its reports
Hyperexcitation after Ketamine 44 reports · 2.3% of its reports

All reported side effects of Tiletamine + Zolazepam in dogs · Medicines most reported with hyperexcitation