Epistaxis after Tepoxalin in dogs

The FDA has received 24 reports of epistaxis in dogs after Tepoxalin. That is 2.2% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

24Reports

0.0%Marked serious

0.0%Recovered

17%Died or euthanised

–Typical onset

How the animals did

Died

4 17%

Not known

20 83%

Problems reported at the same time

Death

4 17%

Blood in stool

3 13%

Labelled drug-drug interaction medication error

3 13%

Lethargy

2 8.3%

Blood problems

2 8.3%

Diarrhea

1 4.2%

Skin petechiae

1 4.2%

Hypoproteinaemia

1 4.2%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Tepoxalin cause epistaxis in dogs?: 24 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Epistaxis with similar medicines

Epistaxis after Melarsomine (Immiticide) 85 reports · 0.4% of its reports
Epistaxis after Polysulfated Glycosaminoglycan 43 reports · 0.8% of its reports
Epistaxis after Cefpodoxime 20 reports · 0.5% of its reports

All reported side effects of Tepoxalin in dogs · Medicines most reported with epistaxis