Neurological signs after Milbemycin Oxime (Interceptor) in dogs

The FDA has received 39 reports of neurological signs in dogs after Milbemycin Oxime. That is 0.1% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported less often than average with this medicine.

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How the animals did

Problems reported at the same time

Age of the animals

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause neurological signs in dogs?

39 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.

What should I do?

Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Neurological signs with similar medicines

• Neurological signs after Ivermectin + Pyrantel (Heartgard Plus) 165 reports · 0.1% of its reports
• Neurological signs after Milbemycin Oxime + Spinosad (Trifexis) 325 reports · 0.3% of its reports
• Neurological signs after Moxidectin (ProHeart 6) 139 reports · 0.3% of its reports
• Neurological signs after Milbemycin Oxime + Praziquantel (Interceptor Plus) 41 reports · 0.1% of its reports
• Neurological signs after Selamectin (Revolution) 69 reports · 0.2% of its reports
• Neurological signs after Ivermectin (Heartgard) 86 reports · 0.7% of its reports

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with neurological signs