Distension of abdomen after Milbemycin Oxime (Interceptor) in dogs

42 reports to the FDA describe distension of abdomen in dogs given Milbemycin Oxime. That is 0.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported less often than average with this medicine.

42Reports
31%Marked serious
7.1%Recovered
29%Died or euthanised
–Typical onset
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How the animals did

Recovered
3 7.1%
Still unwell when reported
6 14%
Died
8 19%
Euthanised
4 9.5%
Not known
21 50%

Problems reported at the same time

Vomiting
22 52%
Lethargy
17 40%
Loss of appetite
17 40%
Death
12 29%
Diarrhea
9 21%
Didn't stop worms
8 19%
Abdominal pain
7 17%
Breathing problems
7 17%

Age of the animals

Under 1 year
6
1–3 years
9
4–7 years
16
8–11 years
8
12+ years
3

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause distension of abdomen in dogs?
42 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Distension of abdomen with similar medicines

All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with distension of abdomen