Cyanosis after Milbemycin Oxime (Interceptor) in dogs
The FDA has received 32 reports of cyanosis in dogs after Milbemycin Oxime. That is 0.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.
32Reports
19%Marked serious
6.3%Recovered
47%Died or euthanised
–Typical onset
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How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).
Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Milbemycin Oxime cause cyanosis in dogs?
- 32 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Cyanosis with similar medicines
- Cyanosis after Ivermectin + Pyrantel (Heartgard Plus) 45 reports · 0.0% of its reports
- Cyanosis after Milbemycin Oxime + Spinosad (Trifexis) 50 reports · 0.0% of its reports
- Cyanosis after Moxidectin (ProHeart 6) 206 reports · 0.4% of its reports
All reported side effects of Milbemycin Oxime in dogs · Medicines most reported with cyanosis