Oral bleeding after Ivermectin + Pyrantel (Heartgard Plus) in dogs
The FDA has received 22 reports of oral bleeding in dogs after Ivermectin + Pyrantel. That is 0.0% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported less often than average with this medicine.
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Ivermectin prevents heartworm disease (monthly). Pyrantel treats roundworms and hookworms.
Products with this combination include Heartgard Plus, Tri-Heart Plus, Iverhart Plus. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.
Questions owners ask
- Can Ivermectin + Pyrantel cause oral bleeding in dogs?
- 22 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Oral bleeding with similar medicines
- Oral bleeding after Milbemycin Oxime + Spinosad (Trifexis) 32 reports · 0.0% of its reports
- Oral bleeding after Moxidectin (ProHeart 6) 55 reports · 0.1% of its reports
All reported side effects of Ivermectin + Pyrantel in dogs · Medicines most reported with oral bleeding