Hyponatremia after Gabapentin in dogs

The FDA has received 60 reports of hyponatremia in dogs after Gabapentin. That is 0.7% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

60Reports

97%Marked serious

3.3%Recovered

32%Died or euthanised

12 daysTypical onset

How soon it started

Same day

4 8.3%

1–2 days

9 19%

3–7 days

8 17%

1–4 weeks

10 21%

Over a month

17 35%

How the animals did

Recovered

2 3.3%

Still unwell when reported

24 40%

Died

8 13%

Euthanised

11 18%

Not known

15 25%

Problems reported at the same time

41 68%

41 68%

37 62%

36 60%

33 55%

31 52%

21 35%

20 33%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Gabapentin used for pain and to reduce stress or anxiety.

Questions owners ask

Can Gabapentin cause hyponatremia in dogs?: 60 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 12 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Hyponatremia with similar medicines

Hyponatremia after Trazodone 21 reports · 0.8% of its reports

All reported side effects of Gabapentin in dogs · Medicines most reported with hyponatremia