Elevated symmetrical dimethylarginine (sdma) after Gabapentin in dogs

131 reports to the FDA describe elevated symmetrical dimethylarginine (sdma) in dogs given Gabapentin. That is 1.5% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

131Reports

69%Marked serious

8.4%Recovered

24%Died or euthanised

31 daysTypical onset

How soon it started

Same day

12 12%

1–2 days

13 13%

3–7 days

9 9.3%

1–4 weeks

14 14%

Over a month

49 51%

How the animals did

Recovered

11 8.4%

Still unwell when reported

60 46%

Died

8 6.1%

Euthanised

23 18%

Not known

29 22%

Problems reported at the same time

97 74%

65 50%

63 48%

50 38%

40 31%

31 24%

29 22%

28 21%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Gabapentin used for pain and to reduce stress or anxiety.

Questions owners ask

Can Gabapentin cause elevated symmetrical dimethylarginine (sdma) in dogs?: 131 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 31 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated symmetrical dimethylarginine (sdma) with similar medicines

Elevated symmetrical dimethylarginine (sdma) after Trazodone 31 reports · 1.2% of its reports

All reported side effects of Gabapentin in dogs · Medicines most reported with elevated symmetrical dimethylarginine (sdma)