Elevated gamma-glutamyl transferase (ggt) after Gabapentin in dogs

130 reports to the FDA describe elevated gamma-glutamyl transferase (ggt) in dogs given Gabapentin. That is 1.4% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported unusually often with this medicine.

130Reports
85%Marked serious
10%Recovered
28%Died or euthanised
17 daysTypical onset
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How soon it started

Same day
17 17%
1–2 days
5 5.0%
3–7 days
8 8.0%
1–4 weeks
33 33%
Over a month
37 37%

How the animals did

Recovered
12 9.2%
Recovered with lasting effects
1 0.8%
Still unwell when reported
47 36%
Died
11 8.5%
Euthanised
25 19%
Not known
34 26%

Problems reported at the same time

Liver problems
117 90%
Loss of appetite
69 53%
Vomiting
57 44%
Lethargy
51 39%
Kidney problems
47 36%
Death
36 28%
Abnormal ultrasound finding
35 27%
Diarrhea
31 24%

Age of the animals

Under 1 year
0
1–3 years
14
4–7 years
33
8–11 years
46
12+ years
36

About this medicine

Gabapentin used for pain and to reduce stress or anxiety.

Questions owners ask

Can Gabapentin cause elevated gamma-glutamyl transferase (ggt) in dogs?
130 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 17 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated gamma-glutamyl transferase (ggt) with similar medicines

All reported side effects of Gabapentin in dogs · Medicines most reported with elevated gamma-glutamyl transferase (ggt)