Elevated amylase after Gabapentin in dogs

87 reports to the FDA describe elevated amylase in dogs given Gabapentin. That is 1.0% of all reports for this medicine, compared with 0.3% across reports for all dog medicines, so it is reported unusually often with this medicine.

87Reports

86%Marked serious

1.1%Recovered

34%Died or euthanised

20 daysTypical onset

How soon it started

Same day

4 6.7%

1–2 days

6 10%

3–7 days

12 20%

1–4 weeks

11 18%

Over a month

27 45%

How the animals did

Recovered

1 1.1%

Still unwell when reported

35 40%

Died

6 6.9%

Euthanised

24 28%

Not known

21 24%

Problems reported at the same time

62 71%

55 63%

50 57%

44 51%

40 46%

32 37%

30 34%

28 32%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Gabapentin used for pain and to reduce stress or anxiety.

Questions owners ask

Can Gabapentin cause elevated amylase in dogs?: 87 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 20 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated amylase with similar medicines

Elevated amylase after Selegiline (Anipryl) 21 reports · 0.5% of its reports
Elevated amylase after Trazodone 32 reports · 1.3% of its reports

All reported side effects of Gabapentin in dogs · Medicines most reported with elevated amylase