Abnormal histology after Gabapentin in dogs

The FDA has received 28 reports of abnormal histology in dogs after Gabapentin. That is 0.3% of all reports for this medicine, compared with 0.0% across reports for all dog medicines, so it is reported unusually often with this medicine.

28Reports

89%Marked serious

11%Recovered

43%Died or euthanised

34 daysTypical onset

How soon it started

Same day

1 5.3%

1–2 days

1 5.3%

3–7 days

1 5.3%

1–4 weeks

5 26%

Over a month

11 58%

How the animals did

Recovered

3 11%

Still unwell when reported

8 29%

Died

5 18%

Euthanised

7 25%

Not known

5 18%

Problems reported at the same time

Death

12 43%

Liver problems

12 43%

Loss of appetite

12 43%

Abnormal radiograph finding

10 36%

9 32%

8 29%

7 25%

7 25%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Gabapentin used for pain and to reduce stress or anxiety.

Questions owners ask

Can Gabapentin cause abnormal histology in dogs?: 28 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 34 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Gabapentin in dogs · Medicines most reported with abnormal histology