Loss of hearing after Enrofloxacin + Silver Sulfadiazine in dogs

The FDA has received 20 reports of loss of hearing in dogs after Enrofloxacin + Silver Sulfadiazine. That is 9.5% of all reports for this medicine, compared with 0.2% across reports for all dog medicines, so it is reported unusually often with this medicine.

20Reports

80%Marked serious

15%Recovered

0.0%Died or euthanised

9 daysTypical onset

How soon it started

Same day

1 6.3%

1–2 days

4 25%

3–7 days

3 19%

1–4 weeks

7 44%

Over a month

1 6.3%

How the animals did

Recovered

3 15%

Still unwell when reported

5 25%

Not known

12 60%

Problems reported at the same time

Swelling

2 10%

Itching

2 10%

Otitis externa

2 10%

Lethargy

1 5.0%

Otitis

1 5.0%

Malodour

1 5.0%

Otorrhoea

1 5.0%

Hiding

1 5.0%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Enrofloxacin treats bacterial infections.

Questions owners ask

Can Enrofloxacin + Silver Sulfadiazine cause loss of hearing in dogs?: 20 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 9 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

All reported side effects of Enrofloxacin + Silver Sulfadiazine in dogs · Medicines most reported with loss of hearing