Skin slough after Cefpodoxime in dogs

The FDA has received 23 reports of skin slough in dogs after Cefpodoxime. That is 0.6% of all reports for this medicine, compared with 0.1% across reports for all dog medicines, so it is reported unusually often with this medicine.

23Reports

35%Marked serious

8.7%Recovered

13%Died or euthanised

7 daysTypical onset

How soon it started

Same day

1 6.7%

1–2 days

3 20%

3–7 days

5 33%

1–4 weeks

2 13%

Over a month

4 27%

How the animals did

Recovered

2 8.7%

Still unwell when reported

11 48%

Died

1 4.3%

Euthanised

2 8.7%

Not known

7 30%

Problems reported at the same time

Skin rash or irritation

14 61%

6 26%

5 22%

5 22%

5 22%

5 22%

4 17%

4 17%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Cefpodoxime cause skin slough in dogs?: 23 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 7 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Skin slough with similar medicines

Skin slough after Melarsomine (Immiticide) 40 reports · 0.2% of its reports
Skin slough after Diphenhydramine 26 reports · 0.6% of its reports
Skin slough after Butorphanol 41 reports · 0.9% of its reports
Skin slough after Famotidine 27 reports · 1.0% of its reports
Skin slough after Tigilanol Tiglate 133 reports · 6.6% of its reports

All reported side effects of Cefpodoxime in dogs · Medicines most reported with skin slough