Ivermectin + Pyrantel (Heartgard Plus) side effects in Mastiffs

401 FDA reports involve Ivermectin + Pyrantel in a Mastiff. These are the problems they describe.

Didn't prevent heartworm
165 41%
Didn't work as expected
82 20%
Didn't stop worms
77 19%
Digestive tract disorder
41 10%
Vomiting
39 9.7%
Cardiac disorder
36 9.0%
Diarrhea
24 6.0%
Lethargy
17 4.2%
Underdose
16 4.0%
Overdose
13 3.2%
Loss of appetite
11 2.7%
Seizures
11 2.7%

All reports for Ivermectin + Pyrantel in dogs