Ivermectin + Pyrantel (Heartgard Plus) side effects in Bullmastiffs

94 FDA reports involve Ivermectin + Pyrantel in a Bullmastiff. These are the problems they describe.

Didn't prevent heartworm
35 37%
Didn't work as expected
22 23%
Digestive tract disorder
16 17%
Didn't stop worms
16 17%
Vomiting
14 15%
Diarrhea
9 9.6%
Cardiac disorder
6 6.4%
Underdose
5 5.3%
Loss of appetite
5 5.3%
Tremors
3 3.2%
Death
3 3.2%
Application site reaction
2 2.1%

All reports for Ivermectin + Pyrantel in dogs