Urine abnormalities after Afoxolaner (NexGard) in dogs
The FDA has received 81 reports of urine abnormalities in dogs after Afoxolaner. That is 0.1% of all reports for this medicine, compared with 0.2% across reports for all dog medicines.
81Reports
59%Marked serious
16%Recovered
9.9%Died or euthanised
14 daysTypical onset
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How soon it started
How the animals did
Problems reported at the same time
Age of the animals
About this medicine
Afoxolaner kills fleas and ticks; given as a monthly chewable.
Products with this ingredient include NexGard. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.
In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.
Questions owners ask
- Can Afoxolaner cause urine abnormalities in dogs?
- 81 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
- How soon after a dose was it reported?
- In half of the reports with dates, it started within 14 days of the first dose.
- What should I do?
- Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).
Urine abnormalities with similar medicines
- Urine abnormalities after Fluralaner (Bravecto) 101 reports · 0.1% of its reports
- Urine abnormalities after Sarolaner (Simparica) 30 reports · 0.2% of its reports
- Urine abnormalities after Lotilaner (Credelio) 43 reports · 0.4% of its reports
All reported side effects of Afoxolaner in dogs · Medicines most reported with urine abnormalities