Recumbency after Afoxolaner (NexGard) in dogs

150 reports to the FDA describe recumbency in dogs given Afoxolaner. That is 0.3% of all reports for this medicine, compared with 0.4% across reports for all dog medicines, so it is reported less often than average with this medicine.

150Reports
74%Marked serious
37%Recovered
25%Died or euthanised
3 daysTypical onset
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How soon it started

Same day
29 24%
1–2 days
29 24%
3–7 days
13 11%
1–4 weeks
18 15%
Over a month
30 25%

How the animals did

Recovered
55 37%
Still unwell when reported
6 4.0%
Died
17 11%
Euthanised
20 13%
Not known
52 35%

Problems reported at the same time

Age of the animals

Under 1 year
14
1–3 years
33
4–7 years
33
8–11 years
41
12+ years
24

About this medicine

Afoxolaner kills fleas and ticks; given as a monthly chewable.

Products with this ingredient include NexGard. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

In 2018 the FDA alerted owners and vets that isoxazoline products have been associated with neurologic reactions such as muscle tremors, wobbliness (ataxia) and seizures, including in animals with no history of them.

Questions owners ask

Can Afoxolaner cause recumbency in dogs?
150 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 3 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Recumbency with similar medicines

All reported side effects of Afoxolaner in dogs · Medicines most reported with recumbency