Elevated symmetrical dimethylarginine (sdma) after Molidustat in cats

34 reports to the FDA describe elevated symmetrical dimethylarginine (sdma) in cats given Molidustat. That is 5.5% of all reports for this medicine, compared with 0.5% across reports for all cat medicines, so it is reported unusually often with this medicine.

34Reports

38%Marked serious

2.9%Recovered

12%Died or euthanised

36 daysTypical onset

How soon it started

Same day

2 7.1%

1–2 days

1 3.6%

3–7 days

3 11%

1–4 weeks

5 18%

Over a month

17 61%

How the animals did

Recovered

1 2.9%

Still unwell when reported

19 56%

Died

2 5.9%

Euthanised

2 5.9%

Not known

10 29%

Problems reported at the same time

Kidney problems

30 88%

Decreased haematocrit

13 38%

Loss of appetite

12 35%

Weight loss

10 29%

Didn't work as expected

9 26%

Hyperphosphataemia

9 26%

Lethargy

9 26%

Behaviour change

7 21%

Age of the animals

Under 1 year

1–3 years

4–7 years

8–11 years

12+ years

About this medicine

Type: medicine.

Questions owners ask

Can Molidustat cause elevated symmetrical dimethylarginine (sdma) in cats?: 34 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?: In half of the reports with dates, it started within 36 days of the first dose.
What should I do?: Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Elevated symmetrical dimethylarginine (sdma) with similar medicines

Elevated symmetrical dimethylarginine (sdma) after Isoflurane 20 reports · 1.0% of its reports

All reported side effects of Molidustat in cats · Medicines most reported with elevated symmetrical dimethylarginine (sdma)