Didn't stop mites after Milbemycin Oxime (Interceptor) in cats

The FDA has received 126 reports of didn't stop mites in cats after Milbemycin Oxime. That is 31% of all reports for this medicine, compared with 1.0% across reports for all cat medicines, so it is reported unusually often with this medicine.

126Reports
5.6%Marked serious
1.6%Recovered
0.8%Died or euthanised
28 daysTypical onset
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How soon it started

Same day
0 0.0%
1–2 days
1 2.4%
3–7 days
4 9.8%
1–4 weeks
16 39%
Over a month
20 49%

How the animals did

Recovered
2 1.6%
Still unwell when reported
11 8.7%
Euthanised
1 0.8%
Not known
112 89%

Problems reported at the same time

Ear discharge
3 2.4%
Otitis externa
1 0.8%
Restlessness or agitation
1 0.8%
Ear pain
1 0.8%
1 0.8%
1 0.8%
1 0.8%

Age of the animals

Under 1 year
47
1–3 years
30
4–7 years
18
8–11 years
11
12+ years
3

About this medicine

Milbemycin Oxime prevents heartworm and controls some intestinal worms (monthly).

Products with this ingredient include Interceptor. The FDA hides brand names in its public data, so these reports cover every product with the same active ingredients.

Some herding breeds (for example Collies) carry the MDR1 gene variant and can be more sensitive to this drug class at high doses.

Questions owners ask

Can Milbemycin Oxime cause didn't stop mites in cats?
126 reports link the two, but a report alone does not prove the medicine was the cause: other illnesses, other medicines or coincidence can be involved. Your vet can judge it for your animal.
How soon after a dose was it reported?
In half of the reports with dates, it started within 28 days of the first dose.
What should I do?
Don't give another dose until you've spoken to your vet, and keep the packaging so you can tell them the product and dose. Your vet can also report it to the FDA (or you can, through the manufacturer or FDA form 1932a).

Didn't stop mites with similar medicines

All reported side effects of Milbemycin Oxime in cats · Medicines most reported with didn't stop mites